What it is
Ketoconazole is a broad-spectrum antifungal medication most commonly used to treat fungal infections of the skin and scalp. It’s often found in medicated shampoos, creams, and prescription treatments. Originally developed for treating conditions like seborrhoeic dermatitis and athlete’s foot, ketoconazole also has mild anti-inflammatory properties, making it useful as a dermatological remedy.
Ketoconazole & Skincare
In skincare and scalp care, ketoconazole works by disrupting the cell membranes of fungi such as Malassezia, a yeast that naturally lives on the skin but can overgrow and trigger inflammation. This yeast is associated with conditions such as dandruff, seborrhoeic dermatitis and fungal acne (more accurately known as Malassezia folliculitis). By reducing the yeast population, ketoconazole helps calm inflammation, relieve itching and restore balance to the skin.
On the face and body, ketoconazole is sometimes prescribed in cream form for treating areas of persistent irritation, redness or breakouts linked to fungal activity. For the scalp, it’s most often used in shampoo form. Regular use can help manage flaking, oiliness and sensitivity associated with overgrowth of yeast.
Emerging research also suggests that ketoconazole may help regulate sebum production and reduce inflammation in some forms of acne, although it’s not a first-line treatment for hormonal acne. Some dermatologists use ketoconazole as part of combination therapy, particularly where fungal and bacterial issues overlap.
It’s important to use ketoconazole as directed, as overuse or misuse can disrupt the skin’s natural microbiome. While generally well-tolerated, ketoconzaole may cause dryness and irritation in some individuals, especially when used alongside other active ingredients.
