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Epidermis

What is it?

The epidermis is the outermost layer of the skin. It acts as the body’s first line of defence, forming a protective barrier against environmental damage, pathogens, and water loss. Despite being only a fraction of a millimetre thick, it plays a vital role in skin health, appearance, and function.

The epidermis is made up mostly of keratinocytes, which produce keratin, a protein that strengthens the skin and helps prevent dehydration. It also contains melanocytes (which produce melanin, the pigment responsible for skin tone), Langerhans cells (which play a role in immune response), and Merkel cells (which help with touch sensation). The balance of these cells contributes to the skin’s ability to protect, repair, and maintain itself.

How does it work?

Because this layer doesn’t contain blood vessels, it relies on the underlying dermis for nutrients and oxygen. Its health depends on a well-functioning skin barrier — often referred to as the acid mantle — which is made up of sebum, sweat, and lipids. When this barrier is intact, skin retains moisture and keeps irritants out. When it’s compromised, skin can become dry, sensitive, inflamed, or prone to infection.

Topical skincare works primarily on the epidermis. Ingredients like AHAs, Retinoids, and Niacinamide target this layer to improve texture, encourage cell turnover, and reduce pigmentation. Moisturisers help to replenish the lipid content of the stratum corneum, reinforcing the barrier and keeping skin soft and hydrated.

The epidermis renews itself roughly every 28 days, though this can slow with age or stress. Supporting this renewal through gentle exfoliation and adequate hydration can help keep skin smooth, clear, and resilient. Sunscreen is also crucial, as UV damage begins at the epidermal level and contributes to premature ageing and skin cancer risk.

The epidermis is where skincare begins, and where small changes can make a visible difference.

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Skinesis Medical at Sarah Chapman
259 Pavilion Rd, Chelsea,
London SW1X 0BP
020 7589 9585

medi@sarahchapman.com

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